Targu Mures is centrally placed in a lowland surrounded by the Carpathian Mountains. The region is crossed by the river Mures, on which a leisure complex was built (Weekend) where there are several swimming pools and areas designed for boating or hydrocycling.

The area has a temperate climate, with 8.2° C annual temperature average and precipitations that can reach 650 mm annually. These characteristics are influenced by the proximity of the mountains (Gurghiu Mountains). Due to the positioning in the Carpathian Mountains, the area is protected from the cold air currents, so even in winter the blizzards are rare.

In the northern part of the city, there is a part of the medieval fortress, built in the early 17th century, with strong walls and imposing towers, in a perfect state of preservation. Inside the fortress there is the Gothic building of the Reformed Church, built in the 14th century. Another tourist area of the city is the central square (Rose Square) where the main architectural symbols of the city are (the Palace of Culture, the Old Town Hall, the Apollo Palace, the National Theatre). Also many buildings with a unique architecture can be visited, such as the Teleki-Bolyai Library, Teleki House, Bányai House, Kopeczi House or Arcade House, as well as a number of museums (ethnography and folk art, natural science, art, history).